Effect of claudin-4 expression on the barrier function of tight junction in epithelial cells treated with tnf-a

• In: Posters: Pharmacokinetics/Pharmacodynamics & Systems Pharmacology
• At: Bangkok (Thailand) (2014)
• Type: Poster
• Poster code: POS-PAA006
• By: WATANABE, Yoshiteru (Showa Pharmaceutical University, Pharmaceutics and Biopharmaceutics, Tokyo, Japan)
• Co-author(s): Matsumoto, Yumi (Showa Pharmaceutical University, Tokyo, Japan)
  Yumoto, Miki (Showa Pharmaceutical University, Tokyo, Japan)
  Koizumi, Naoya (Showa Pharmaceutical University, Tokyo, Japan)
  Fujii, Makiko (Showa Pharmaceutical University, Tokyo, Japan)
  
• Abstract:

  Background: The disruption of tight junction (TJ) barrier functions for many hours can have undesirable side effects, such as inflammatory bowel disease caused by cytokines, thus TJ reformation rate will be important for therapy. Caludin-4, one of major component localized to most apical cell-cell contacts, has been reported to control TJ barrier..

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