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Development of sprayable in situ gelling system for nasal donepezil delivery: preliminary formulation and deposition studies

  • At: Seville (Spain) (2022)
  • Type: Poster
  • Poster code: DDD-022
  • By: PERKUSIC, Mirna (University of Zagreb Faculty of Pharmacy and Biochemistry, Department of Pharmaceutical Technology, Croatia)
  • Co-author(s): Ms Mirna Perkusic, Research Assistant, Phd Student (University of Zagreb Faculty of Pharmacy and Biochemistry, Department of Pharmaceutical Technology, Zagreb, Croatia)
    Ms Laura Nižić Nodilo, Department of Pharmaceutical Technology (University of Zagreb Faculty of Pharmacy and Biochemistry, Department of Pharmaceutical Technology, Zagreb, Croatia)
    Ms Cvijeta Jakobušić Brala, Department of Physical Chemistry (University of Zagreb Faculty of Pharmacy and Biochemistry, Department of Physical Chemistry, Zagreb, Croatia)
    Mr Ivan Pepić, Department of Pharmaceutical Technology (University of Zagreb Faculty of Pharmacy and Biochemistry, Department of Pharmaceutical Technology, Zagreb, Croatia)
    Ms Vesna Saršon (Jadran-galenski laboratorij d.d., Rijeka, Croatia)
    Ms Maša Safundžić Kučuk (Jadran-galenski laboratorij d.d., Rijeka, Croatia)
    Ms Dijana Zadravec, 3Department of Diagnostic and Interventional Radiology, Sestre milosrdnice University Hospital Center, University of Zagreb (Department of Diagnostic and Interventional Radiology, Sestre milosrdnice University Hospital Center, University of Zagreb, Zagreb, Croatia)
    Mr Livije Kalogjera, ENT Department (ENT Department, Zagreb School of Medicine; Sestre milosrdnice University Hospital Center, Zagreb, Croatia)
    Ms Anita Hafner, Department of Pharmaceutical Technology (University of Zagreb Faculty of Pharmacy and Biochemistry, Department of Pharmaceutical Technology, Zagreb, Croatia)
  • Abstract:

    BACKGROUND
    Due to disadvantages of oral administration of anti-dementia drug donepezil, nose-to-brain delivery attracts much attention as more efficient and safe route of administration (1). Nasal drug administration enables delivery to the central nervous system via olfactory nerve that innervates olfactory region of the nasal cavity. To ensure..

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Last update 28 September 2023

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