DICLOFENAC INDUCED LIVER INJURY IN HEPATOCYTES CO-CULTURED WITH MACROPHAGES
- At: AbuDhabi (United Arab Emirates) (2019)
- Type: Poster
- Poster code: POS-PAA-003
- By: KAWASE, Atsushi (Kindai University, Japan)
- Co-author(s): Atsushi Kawase: Department of Pharmacy, Kindai University, Osaka, Japan
Rio Yamashita: Department of Pharmacy, Kindai University, Osaka, Japan
Hiroaki Shimada: Department of Pharmacy, Kindai University, Osaka, Japan
Masahiro Iwaki: Department of Pharmacy, Kindai University, Osaka, Japan - Abstract:
Background
Reactive metabolites of diclofenac (DIC) such as DIC acyl-β-D-glucuronide (DIC-AG) form the covalent protein binding in hepatocytes (HC) following a decrease of protein function or inducing an immune response. However, the precise mechanisms of drug-induced liver injury (DILI) remain unclear. This lack of mechanistic understanding makes.. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.
Please login
Last update 28 September 2023