In vitro and in vivo studies of inhibition of hepatic enzymes to address the risk of herb-drug interactions

• In: SIG Natural Substances - Posters
• At: Beijing (China) (2007)
• Type: Poster
• Poster code: NS-P-105
• By: HU, Oliver Yoa-Pu (National Defense Medical Center, Taipei, China Taiwan)
• Co-author(s): Hsiong, Cheng-Huei (National Defense Medical Center, TAIPEI, China Taiwan)
  Pao, Li-Heng (National Defense Medical Center, TAIPEI, China Taiwan)
  Hung, Chi-Fung (National Defense Medical Center, TAIPEI, China Taiwan)
  
• Abstract:

  Aims:To evaluate the metabolic effects and the potential herb-drug interactions for traditional Chinese medicine (TCM). Methods:A cocktail contained with human liver microsome and was consisted of CYP- and UGT-selective probes: ethoxyresorufin (CYP1A2), dextromethophan (CYP2D6), testosterone (CYP3A4), tolbutamide (CYP2C9) and morphine (UGT2B7)...

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