Improved solubility, dissolution and bioavailability of ibuprofen using solid dispersions with poloxamer 407.

• In: Industrial Pharmacy Section - Posters
• At: Beijing (China) (2007)
• Type: Poster
• Poster code: IPS-P-018
• By: YONG, Chul Soon (Yeungnam University, Gyoungsan, South-Korea)
• Co-author(s): Choi, H. G. (Yeungnam University, GYOUNGSAN, South-Korea)
  Kwak, M. K. (Yeungnam University, GYOUNGSAN, South-Korea)
  Rhee, J. D. (Yeungnam University, GYOUNGSAN, South-Korea)
  Yoo, B. K. (Yeungnam University, GYOUNGSAN, South-Korea)
  Kim, J. A. (Yeungnam University, GYOUNGSAN, South-Korea)
  Lyoo, W. S. (Yeungnam University, GYOUNGSAN, South-Korea)
  Newa, M. (Yeungnam University, GYOUNGSAN, South-Korea)
  Bhandari, K. H. (Yeungnam University, GYOUNGSAN, South-Korea)
  
• Abstract:

  Aim: To prepare the solid dispersions containing ibuprofen as a poorly water soluble by low temperature melting method in order to improve its solubility, dissolution rate and bioavailability using poloxamer 407 as a meltable hydrophilic polymer carrier
  
  Methods: Phase solubility behavior of ibuprofen at 25ËšC in various molar solutions of..

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