QUANTITATIVE EFFECT OF CYP2C19 AND CYP2C9 GENOTYPE ON CONCENTRATION PREDICTION OF VALPROATE IN EPILEPTIC PATIENTS

• In: C5 - Short oral presentations – focus on science & industry on Wednesday, 30 September 2015, 14:30-17:30
• At: Düsseldorf (Germany) (2015)
• Type: Presentation
• By: JIANG, Dechun (XuanWu Hospital of Capital Medical University, Department of Pharmacy, Beijing, China)
• Co-author(s): Dechun Jiang
  
• Abstract:

  Valproate (VPA) application is very difficult to handle because of the significant individual pharmacokinetic variability.

  Different genotypes had different influence on the VPA serum concentration. However, the influence of genotype on the prediction of drug serum concentration is unknown.

  Three Population pharmacokinetic (PK) models which included 

  ..

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