Regulatory mechanisms influencing drug transport across the blood-brain barrier

• In: APSA SYMPOSIUM: BARRIER MECHANISMS TEAM UP: INTERPLAY BETWEEN TRANSPORTERS, ENZYMES AND TIGHT JUNCTIONS on Tuesday, 15 April 2014, 10:30-12:00
• At: PSWC, Melbourne (Australia) (2014)
• Type: Presentation
• By: ELMQUIST, William F. (University of Minnesota, Pharmaceutics, Minneapolis, minnesota, United States of America)
• Co-author(s): Parrish, Karen (University of Minnesota, Minneapolis, minnesota, United States of America)
  Iyekegbe, Dennis (Mayo Clinic, Rochester, minnesota, United States of America)
  Mittapalli, Rajendar (University of Minnesota, Minneapolis, minnesota, United States of America)
  Oberoi, Rajneet (University of Minnesota, Minneapolis, minnesota, United States of America)
  Vaidhyanathan, Shruthi (University of Minnesota, Minneapolis, minnesota, United States of America)
  Sarkaria, Jann (Mayo Clinic, Rochester, minnesota, United States of America)
  
• Abstract:

  This talk will describe the interplay between various mechanisms that limit drug transport across the blood-brain barrier (BBB). These mechanisms include transport systems and tight junctions in the capillary endothelial cells of the brain microvasculature. Studies recently published strongly suggest a role for sonic hedgehog signaling through the ..

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