B1 One size doesn’t fit all: Dose individualisation with population pharmacology
Tuesday 12 September 2017
09:00-12:00
COEX Convention & Exhibition Center : Grand Ballroom 105 3 hours
Organised by the FIP Programme Committee and the FIP Special Interest Group on PK/PD & Systems Pharmacology
Chairs: Don Mager (University at Buffalo, USA) and Michael Ward (University of South Australia, Australia)
Introduction
Most medicines have been developed for an “average” patient, with little to no concern for medicine responses in specific patient subpopulations or individuals. This “one-size-fits-all” approach often results in good performance in some patients but less than successful treatment outcomes in many others, including poor efficacy and/or adverse medicine reactions. This session directly addresses the critical unmet medical need of individualised pharmacotherapy. Population pharmacology enables personalised medicine therapy through the effective integration of individual patient characteristics, pharmacokinetic and pharmacodynamic principles, and computational algorithms capable of handling big data and mathematical models of medicine action.
Learning objectives
At the end of this knowledge -based session, the participants will be able to:
- Describe basic population-based pharmacokinetic-pharmacodynamic principles that underlie dosing regimen individualisation in specific diseases and special populations.
- Describe approaches for integrating pharmacogenomic data in population-based analyses for identifying sources of variability in medicine action.
Specify the utility of population pharmacology and feedback measurements obtained from patients for individualising warfarin and antibiotic dose individualisation.
Programme
09:00 – 09:40
1. Basic principles of applied pharmacometrics
Speaker TBA
09:40 – 10:20
2. Development of a model-based dose-individualisation approach with an application to routine clinical data
Jinju Guk (Yonsei University College of Medicine, Republic of Korea)
10:20 – 10:40 Coffee/tea break
10:40 – 11:20
3. Dose-individualisation of anticoagulants
Don Mager (University at Buffalo, USA)
11:20 -12:00
4. Optimising antimicrobial dosing regimens in clinical practice
Markus Zeitlinger (Medical University of Vienna, Austria)