SOLVING PRACTICAL TABLETING PROBLEMS
Tuesday 6th of September 2011
09:00-12:00
D5
Organised by IPS
Learning objectives
At the conclusion of this session, participants will be able to:
- Describe the main challenges of developing robust tableting processes
- Discuss the steps that can be taken to overcome some of the most common tableting problems, like tablet sticking to tooling and inadequate content uniformity
- Explain the impact of advanced process analytical approaches and the possibilities of root cause analysis
Programme
- Recent developments in excipient and drug substance technology enabling robust tableting processes: Nandu Deorkar (Avantor, USA)
- Evaluation of the effects of tableting variables on drug stability: A case study with Gabapentin: Mansoor Khan (FDA, USA)
- Fluorescence based PAT for improved control over the blending and tableting process including PAT blending demo Charles Kettler (Natoli Engineering, USA)
- Tablet sticking & tooling - Report of the Industrial Pharmacy Working Group Tom Sam (MSD, The Netherlands)
- Science based trouble shooting of the tableting process. Tablet defects – Root cause analysis Nicolaos D. Gentis (University of Basel, Switzerland)
- Tablet splitting: Implications of compositional and compressional factors on dose variability: Mansoor Khan (FDA, USA)
- Industrial pharmacy posters on solid dosage forms from universities and industry as presented at the FIP congress: Moderator Tom Sam (Merck Sharp & Dohme, The Netherlands)
