Preventing the blood-brain barrier disruptive effects of lipopolysaccharide with polymyxin analogues

• In: Posters H - Pharmacology
• At: PSWC, Melbourne (Australia) (2014)
• Type: Poster
• Poster code: PH-008
• By: MCINERNEY, Mitchell (Monash University, Faculty of Pharmaceutical Sciences, Melbourne, Australia)
• Co-author(s): Nicolazzo, Joseph (Monash University, Melbourne, Australia)
  Jin, Liang (Monash University, Melbourne, Australia)
  Nation, Roger (Monash University, Melbourne, Australia)
  Li, Jian (Monash University, Melbourne, Australia)
  Velkov, Tony (Monash University, Melbourne, Australia)
  
• Abstract:

  Background information: The frequency of multidrug-resistant bacteria appearing in the clinic is increasing. These species release toxic molecules called lipopolysaccharides (LPS) which have the ability to cause tight junction disruption in the blood-brain barrier (BBB) and subsequent BBB hyper-permeabilisation. Previous studies have demonstrated..

The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress. Please login