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Modulation of P-glycoprotein function and sensitivity to anticancer drug by Azadirachta indica extract in multidrug resistant cell lines

  • In: Poster Presentation
  • At: Stockholm (Sweden) (2017)
  • Type: Poster
  • Poster code: P-A-081-Monday
  • By: KAWAMI, Masashi (Hiroshima University, Graduate school of Biomedical & Health Sciences, Pharmaceutics and Therapeutics, Hiroshima, Japan)
  • Co-author(s): Masashi Kawami: Pharmaceutics and Therapeutics, Graduate school of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan
    Yukinori Yamada: Pharmaceutics and Therapeutics, Graduate school of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan
    Ousanee Issarachot: Center of Excellence in Innovative Drug Delivery and Nanomedicine, Mahidol University, Bangkok, Thailand
    Varaporn Junyaprasert: Center of Excellence in Innovative Drug Delivery and Nanomedicine, Mahidol University, Bangkok, Thailand
    Ryoko Yumoto: Pharmaceutics and Therapeutics, Graduate school of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan
    Mikihisa Takano: Pharmaceutics and Therapeutics, Graduate school of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan
  • Abstract:

    Backgrounds

    P-Glycoprotein (P-gp; ABCB1), a member of ATP-binding cassette transporters, is well known to confer multidrug resistance to various cancer cells. At this moment, however, P-gp modulator is not yet available for clinical use, partly due to the toxicity of the modulator. We have been studying P-gp modulating effects of various Thai plant ..

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Last update 28 September 2023

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