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How can modelling ensure enough exposure in SAD? – a case study of administration optimization
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-A-068-Monday
- By: CARLERT, Sara (AstraZeneca, Pharmaceutical Sciences, Mölndal, Sweden)
- Co-author(s): Sara Carlert: Pharmaceutical Sciences, AstraZeneca, Mölndal, Sweden
Christer Tannergren: Pharmaceutical Technology and Development, AstraZeneca, Mölndal, Sweden - Abstract:
Backgrounds
Escalating single dose studies of AZ1 showed limitations in exposure above doses of 200 mg that were likely solubility related, which could potentially jeopardize the future clinical study plan. Time delays for more than a couple of weeks were not permitted, which excluded reformulation of the drug.Aims
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Last update 28 September 2023