Targeting TRPM2 Signaling to Relieve Brain Pericyte Injury

• In: Short Communications A3 on Tuesday, 23 May 2017, 11:15-12:30
• At: Stockholm (Sweden) (2017)
• Type: Presentation
• By: LU, Yingmei (Zhejiang University City College, Hangzhou, China)
• Co-author(s): Lingxiao Shao: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
  Quan Jiang: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
  Ninghe Sun: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
  Danyang Chen: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
  Xiuxiu Liu: School of Medicine, Zhejiang University City College, HangZhou, China
  Yue Pan: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
  Yijie Liu: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
  Fangying Yu: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
  Feng Han: College of pharmaceutical sciences, Zhejiang university, HangZhou, China
  
• Abstract:

  Backgrounds

  Dysfunction of neurovascular pericytes underlies the breakdown of the blood-brain barrier, but the molecular mechanisms are largely unknown.

  Aims

  In this study, we evaluated the role of the TRPM2 (transient receptor potential melastatin-related 2) channel and autophagy during brain pericyte injury in vitro and in vivo.

  Methods

  Moni

  ..

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