A comparison of two different self immolative linker strategies in the design of lymph directing, triglyceride mimetic prodrugs of buprenorphine

• In: Short Communications A2 on Monday, 22 May 2017, 13:30-15:00
• At: Stockholm (Sweden) (2017)
• Type: Presentation
• By: HAN, Sifei (Monash University, Drug Delivery, Disposition and Dynamics, Parkville, Australia)
• Co-author(s): Sifei Han: Drug Delivery, Disposition and Dynamics, Monash University, Parkville, Australia
  Luojuan Hu: Drug Delivery, Disposition and Dynamics, Monash University, Parkville, Australia
  Tim Quach: Medicinal Chemistry, Monash University, Parkville, Australia
  Shea Lim: Medicinal Chemistry, Monash University, Parkville, Australia
  Natalie Trevaskis: Drug Delivery, Disposition and Dynamics, Monash University, Parkville, Australia
  Jamie Simpson: Medicinal Chemistry, Monash University, Parkville, Australia
  Christopher Porter: Drug Delivery, Disposition and Dynamics, Monash University, Parkville, Australia
  
• Abstract:

  Backgrounds

  The oral bioavailability of buprenorphine (BUP) is limited by hepatic first-pass metabolism. Exploiting drug transport through the lymphatic system provides a means to circumvent first pass metabolism, since the intestinal lymph drains into the systemic circulation via the thoracic duct, bypassing the liver. Previous studies have

  ..

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