Frequency of sterigmatocystin (stc)-producing dustborne aspergilli from flooded and unflooded houses in croatia – employment of hplc/dad/ms method in stc exposure assessment

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: SERTIć, Miranda (University of Zagreb Faculty of Pharmacy and Biochemistry, Department of analytics and control of medicines, Zagreb, Croatia)
  • Co-author(s): Miranda Sertic: University of Zagreb Faculty of Pharmacy and Biochemistry, Zagreb, Croatia
    Daniela Jakšić Despot: University of Zagreb Faculty of Pharmacy and Biochemistry, Zagreb, Croatia
    Ana Mornar: University of Zagreb Faculty of Pharmacy and Biochemistry, Zagreb, Croatia
    Domagoj Kifer: University of Zagreb Faculty of Pharmacy and Biochemistry, Zagreb, Croatia
    Biljana Nigović: University of Zagreb Faculty of Pharmacy and Biochemistry, Zagreb, Croatia
    Maja Šegvić Klarić: University of Zagreb Faculty of Pharmacy and Biochemistry, Zagreb, Croatia
  • Abstract:

    Background: STC is precursor of aflatoxin and also the end product in biosynthesis of Aspergilli from the section Versicolores.
    Mechanism of STC toxicity is transformation by CYP monooxygenases into epoxide, which forms DNA-adducts leading to
    hepatotoxicity and carcinogenicity. STC-producing Aspergilli are frequently airborne in damp dwellings and

    ..

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