Preparation of rivaroxaban nanocrystals with wet ball milling

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: DEMIR, Huriye (Hacettepe University Faculty of Pharmacy, Department of Pharmaceutical Technology, ANKARA, Turkey)
  • Co-author(s): Huriye Demir : Department of Pharmaceutical Technology, Hacettepe University Faculty of Pharmacy, ANKARA, Turkey
    Selma Sahin: Department of Pharmaceutical Technology, Hacettepe University Faculty of Pharmacy, ANKARA, Turkey
    Levent Oner: Department of Pharmaceutical Technology, Hacettepe University Faculty of Pharmacy, ANKARA, Turkey
  • Abstract:

    Methods

    Rivaroxaban as the model compound, pluronic F127 and PVP K-30 as surfactant and stabilizer were used for the preparation of nanocrystal formulation. The nanocrystals were prepared by wet ball milling method and lyophilisation. RXB (0.5% w/v) was added to pluronic F127 (0.5%, w/v) and PVP K-30 (0.5%, w/v) solution under continuous magnetic

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