Polyamidoamine-decorated nanodiamonds as a hybrid gene delivery vector and sirna structural characterization at the charged interfaces

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: JEONG, Seong Hoon (Goyang, Korea, Republic Of)
  • Co-author(s): Seong Hoon Jeong
    Dae Gon Lim
    Eunah Kang
    Young Kee Shin
    Hun Soon Jung
  • Abstract:

    Methods

    A spectral study of siRNA/PAMAN-ND complexes using differential scanning calorimetry (DSC) and circular dichroism spectroscopy (CD) proved that the hydrogen bonding and electrostatic interaction between siRNA and PAMAN-NDs decreased endothermic heat capacity. Moreover, siRNA/PAMAN-ND complexes showed low cell cytotoxicity and significant..

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