Development and evaluation of lyophilized orally disintegrating tablets containing metformin hydrochloride and glyburide

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: AKDAG CAYLI, Yagmur (Hacettepe University, Pharmaceutical Technology, Turkey)
  • Co-author(s): Yagmur Akdag Cayli:
    Tugba Gulsun: Pharmaceutical Technology, Hacettepe University, Ankara, Turkey
    Nihan Izat: Pharmaceutical Technology, Hacettepe University, Ankara, Turkey
    Meltem Cetin: Pharmaceutical Technology, Atatürk University, Erzurum, Turkey
    Levent Oner: Pharmaceutical Technology, Hacettepe University, Ankara, Turkey
    Selma Sahin: Pharmaceutical Technology, Hacettepe University, Ankara, Turkey
  • Abstract:

    Methods

    MH and GB containing ODTs (250:2.5 mg) were prepared using gelatine, mannitol, sodium alginate, PEG 4000, Pluronic F68, hydroxypropyl methyl cellulose and simethicone.

    Gelatine was swelled in pre-heated distilled water (40-50°C) for 30 min, then other excipients were added one by one on a magnetic stirrer. Finally, MH and GB were added. The

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