Oral delivery of an anticancer drug in the treatment of acute myeloid leukemia

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: JAIN, Prateek (Decision Resources Group, Biopharma Insights, Gurgaon, India)
  • Co-author(s): Prateek Jain
    Nayanabhirama Udupa
    J Venkata Rao
  • Abstract:

    Methods

    We fabricated decitabine loaded PLGA nanoparticles (DEC-NPs) for potential oral delivery of DEC, by multiple emulsion solvent evaporation; and characterized by various studies.

    Results

    The optimized formulation had PS 124.3±4.2 nm, ZP -23.2±1.2 mV, and EE of 41.8±4.3%. The drug release from NPs was slower and sustained. The Cmax of DEC-NPs ..

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