Synthesis and in vitro cytotoxic activities of some novel steroidal semicarbazones

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: CAKAR, Uros (Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia)
  • Co-author(s): Uros Cakar: Department of Bromatology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
    Marijana Zivkovic: Department of Chemistry, Institute for Chemistry, Technology and Metallurgy, Belgrade, Serbia
    Ivana Matic: Institute of Oncology and Radiology of Serbia, Belgrade, Serbia
    Dusan Sladic: Faculty of Chemistry, University of Belgrade, Belgrade, Serbia
    Natalija Krstic: Institute of Oncology and Radiology of Serbia, Belgrade, Serbia
  • Abstract:

    Methods

     SCs (2a-d and 3a-d) were obtained by refluxing a mixture of semicarbazide hydrochloride (6 mmol), sodium acetate (3.6 mmol), and steroidal ketones (1a-d) (6 mmol) in ethanol (300 mL) for 1 h. HeLa cells were seeded into 96-well plates. 20 h later, DMSO solutions of the examined compounds were added to the cells. Cell survival was

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