Solubilisation of ibuprofen in mixed-surfactant systems containing poloxamer 407 and selected polioxyethylene-derivative surfactants

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: PLUTA, Janusz (Polish Pharmaceutical Society, Department of Drug Form Technology, Warsaw, Poland)
  • Co-author(s): Janusz Pluta: Department of Drug Form Technology, Faculty of Pharmacy, Wroclaw Medical University, Wrocław, Poland;Department of Pharmacology, Opole Medical School (PMWSZ), Opole, Poland
    Kamil P Grela: Department of Drug Form Technology, Faculty of Pharmacy, Wroclaw Medical University, Wrocław, Poland
    Dominik M Marciniak: Department of Drug Form Technology, Faculty of Pharmacy, Wroclaw Medical University, Wrocław, Poland
    Anna Cap:
    Jakub Burak: Department of Drug Form Technology, Faculty of Pharmacy, Wroclaw Medical University, Wrocław, Poland
  • Abstract:

    Methods

    The excess of IBU was added to aqueous solutions of P407 (17% w/w), enriched with chosen polyoxyethylene alkyl ethers (Brij® 35, 76; 0.25-0.5% w/w) and polyoxyethylene stearates (Myrj® 52, 53; 0.5 % w/w). The same procedure was performed for PEX solutions without P407, for the pure P407 solution, and for pure water. Samples have been agitate..

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