Improvement of neuro-degeneration in a multiple system atrophy animal model by human bone marrow-derived mesenchymal stem cells

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: HWANG, Chul Ju (Chungbuk National University, Cheongju, Korea, Republic Of)
  • Co-author(s): Chul Ju Hwang:
    Mi Hee Park: Chungbuk National University, Cheongju, Korea, Republic Of
    In Jun Yeo: Chungbuk National University, Cheongju, Korea, Republic Of
    Dong-Young Choi: Yeungnam University, Gyeongsan, Korea, Republic Of
    Pil-Hoon Park: Yeungnam University, Gyeongsan, Korea, Republic Of
    Hyung Sook Kim: Corestem Inc, Seongnam, Korea, Republic Of
    Jung Tae Lee: Corestem Inc, Seongnam, Korea, Republic Of
    Young Suk Jung: Pusan National University, Busan, Korea, Republic Of
    Sang-Bae Han: Chungbuk National University, Cheongju, Korea, Republic Of
    Jin Tae Hong: Chungbuk National University, Cheongju, Korea, Republic Of
  • Abstract:

    Methods

    To induce the degeneration of nigral neurons, 6-hydroxydopamine (6-OHDA; 40 μg/kg) was intracerebroventricularly injected, followed by quinolinic acid (QA; 300 nmol/kg) after 3 weeks. After 2 weeks, MSCs were transplanted (1.2×105 and 6×105) via intra-arterial or intrathecal injections. 

    Results

    We found that behavioral disorder..

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