Physicochemical, pharmacokinetic, and anticancer activity analysis of self-assembled polyelectrolyte complex micelles encapsulated cationic drugs

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: KIM, Jong Oh (Yeungnam University, Gyeongsan-si, Korea, Republic Of)
  • Co-author(s): Woo Hyun Shin: Yeungnam University, Gyeongsan-si, Korea, Republic Of
    Hima Bindu Ruttala: Yeungnam University, Gyeongsan-si, Korea, Republic Of
    Milan Gautam: Yeungnam University, Gyeongsan-si, Korea, Republic Of
    Jee-Heon Jeong: Yeungnam University, Gyeongsan-si, Korea, Republic Of
    Dong Shik Kim: Hanyang University, Ansan-si, Korea, Republic Of
    Han-Gon Choi: Hanyang University, Ansan-si, Korea, Republic Of
    Chul Soon Yong: Yeungnam University, Gyeongsan-si, Korea, Republic Of
    Jong Oh Kim: Yeungnam University, Gyeongsan-si, Korea, Republic Of
  • Abstract:

    Methods

    Individual DOX and MTX-loaded polyelectrolyte complex micelles (PCM) were prepared, and their physicochemical properties and pH-responsive release profiles were studied.

    Results

    MTX-PCM and DOX-PCM exhibited a different release profile under all pH conditions tested. MTX-PCM exhibited a monophasic release profile with no initial burst,..

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