Polypeptide nanovehicle co-encapsulating doxorubicin and quercetin for a synergistic combination to enhance chemotherapeutic activity in solid tumors

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: YONG, Chul Soon (Yeungnam University, Gyeongsan-Si, Korea, Republic Of)
  • Co-author(s): Woo Hyun Shin: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
    Hima Bindu Ruttala: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
    Phung Cao Dai: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
    Myung-Ja Hong: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
    Jee-Heon Jeong: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
    Dong Shik Kim: Hanyang University, Ansan-si, Korea, Republic Of
    Han-Gon Choi: Hanyang University, Ansan-si, Korea, Republic Of
    Chul Soon Yong: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
    Jong Oh Kim: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
  • Abstract:

    Methods

    The block copolymer was synthesized and the preparation of the DOX/QUR-loaded polypeptide-based nanovehicle (DQ-NV) was prepared by dialysis. Further, the nanoparticle was investigated by several physicochemical, invitro release study, cell studies were performed. Also, the invivo antitumor and histology studies performed using SCC7 tumor..

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