Layer-by-layer assembly of polyarginine and poly(ethylene glycol)-block-poly (l-aspartic acid) polymers to enhance the systemic performance of albumin-bound paclitaxel nanoparticle

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: YONG, Chul Soon (Yeungnam University, Gyeongsan-Si, Korea, Republic Of)
  • Co-author(s): Woo Hyun Shin: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
    Hima Bindu Ruttala: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
    Jae-Myung Lee: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
    Dong Shik Kim: Hanyang University, Ansan-si, Korea, Republic Of
    Jee-Heon Jeong: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
    Han-Gon Choi: Hanyang University, Ansan-si, Korea, Republic Of
    Chul Soon Yong: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
    Jong Oh Kim: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
  • Abstract:

    Methods

    We studied the systemic stability of nab-PTX and LBL-nPTX in an animal model, and respective pharmacokinetic parameters were modeled by non-compartmental analysis using WinNonlin software.

    Results

    LbL-based nab-PTX was fabricated by the alternate deposition of polyarginine(pARG) and poly(ethylene glycol)-block-poly(L-aspartic acid)..

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