Molecularly targeted dual drug loaded lipid-protein hybrid nanoparticles for synergistic combinational chemotherapy

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: YONG, Chul Soon (Yeungnam University, Gyeongsan-Si, Korea, Republic Of)
  • Co-author(s): Jae Hee Kim: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
    Hima Bindu Ruttala: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
    Gyeong Jin An: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
    Myung-Ja Hong: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
    Jee-Heon Jeong: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
    Dong Shik Kim: Hanyang University, Ansan-si, Korea, Republic Of
    Han-Gon Choi: Hanyang University, Ansan-si, Korea, Republic Of
    Chul Soon Yong: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
    Jong Oh Kim: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
  • Abstract:

    Methods

    We have developed a custom-designed procedure in which thin lipid-film layer was applied to the round-bottomed glass surface, overlaid with PTX/VOR-loaded albumin NP, and subsequently surface conjugated with Tf.

    Results

    Tf-L-APVN exhibited a sequential and controlled release profile of paclitaxel and vorinostat, with an accelerated release ..

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