Cd9-targeted delivery of rapamycin for anti-senescence activity in human dermal fibroblasts

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: YONG, Chul Soon (Yeungnam University, Gyeongsan-Si, Korea, Republic Of)
  • Co-author(s): Jong Seong Lee: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
    Hanh Thuy Nguyen: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
    Raj Kumar Thapa: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
    Zar Chi Soe: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
    Dong Shik Kim: Hanyang University, Ansan-si, Korea, Republic Of
    Han Gon Choi: Hanyang University, Ansan-si, Korea, Republic Of
    Chul Soon Yong:
    Jong Oh Kim: Yeungnam University, Gyeongsan-Si, Korea, Republic Of
  • Abstract:

    Methods

    Liposomes, which were prepared by extrusion method, were conjugated with CD9 monoclonal antibody (LR-CD9mAb). Liposomes then were characterized the physical properties and the in vitro anti-aging effect on human dermal fibroblasts (HDFs).

    Results

    LR-CD9mAb has a small particle size(143.3±2.4 nm), narrow size distribution(polydispersity..

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