Effect on pvp / tadalafil solid dispersion prepared using supercritical anti-solvent method with operating parameters

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: HAM, Gun Joo (Korea, Republic Of)
  • Co-author(s): Gun Joo Ham: College of pharmacy, Yonsei university, Incheon, Korea, Republic Of
    In Taek Shin: College of pharmacy, Yonsei university, Incheon, Korea, Republic Of
    Sung-Joo Hwang: College of pharmacy, Yonsei university, Incheon, Korea, Republic Of
  • Abstract:

    Methods

    The SAS process was used to investigate the effect of process parameters on average particle sizes of tadalafil solid dispersion. Also to clarify in vitro characteristics such as crystallization, investigation was made using powder X - ray diffraction (PXRD).

    Results

    The mean particle size decreased when temperature decreased 50 to 40,..

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